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Saturday, July 25, 2020 | History

3 edition of Studies of chromogranin A found in the catalog.

Studies of chromogranin A

Karen B. Helle

Studies of chromogranin A

a protein of the catecholamine-storing organelles of the adrenal medulla and the adrenergic neuron

by Karen B. Helle

  • 234 Want to read
  • 25 Currently reading

Published by Universitetsforlaget in Bergen .
Written in

    Subjects:
  • Chromaffin cells.,
  • Chromogranins.,
  • Catecholamines -- Metabolism.,
  • Adrenal medulla.,
  • Cattle -- Physiology.

  • Edition Notes

    Statementby Karen B. Helle.
    Classifications
    LC ClassificationsQP188.C35 H44
    The Physical Object
    Pagination1 v. (various pagings)
    ID Numbers
    Open LibraryOL3899630M
    LC Control Number81461720

    The aim of this study was to assess the value of plasma chromogranin A (CgA), a protein produced by neuroendocrine cells, in the diagnosis of neuroendocrine tumours. Eighty subjects with. Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins, i.e., it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in pancreas. In humans, chromogranin A protein is encoded by the CHGA g: book.

    We have recently studied the effects of chromogranin A transfection on highly malignant cell lines and have reported that transfection of chromogranin A inhibits the growth of various types of tumors. His laboratory plans to study the mechanism of this action. Another area of study for Dr. Lloyd has been carcinoid tumors. Introduction: Chromogranin A (CgA) is the most frequently used marker in well- (grade 1) and moderately (grade 2) differentiated NETs. Although CgA is a more sensitive marker than the 5-HIAA, which was widely used until the last decade, CgA has some limitations. False-positively elevated CgA may occur in renal impairment, atrophic gastritis and during treatment of proton-pump g: book.

    Study Using Chromogranin A as Surveillance Biomarker in Patients with cARcinoids Rochester, MN The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II KRYPTOR Assay in patients with Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs). Immunohistochemical analysis is the most effective method for the diagnosis of PHNETs. In our study, representative immunohistochemical markers, such as CK AE1/AE3, synaptophysin, chromogranin A and CD56, were positive (Fig. 2). Additionally, hepatocyte antigen and CK7, which are not expressed in NETs, were negative (Fig. 2).


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Studies of chromogranin A by Karen B. Helle Download PDF EPUB FB2

Chromogranin A (CgA) is an acidic glycoprotein with a molecular mass of 49 kd that is widely expressed by neuroendocrine cells and constitutes one of the most abundant components of secretory granules. 1 CgA is physiologically released by exocytosis and may be detected in the blood.

In particular, when a tumor develops in an endocrine tissue, it becomes the main source of circulating Cited by: Comparative Studies of the Chromogranin A-Derived Neuropeptide WE Author(s): W.

Curry, J. Quinn, S. Brockbank, V. Miller, C. McVicar, K. Pogue, S. Barkatullah, P. by: 1. Chromogranin A. CgA is an important tissue and serum marker for different types of carcinoid tumors, including those of the foregut, midgut, and hindgut (see Table and later discussion).

From: Williams Textbook of Endocrinology (Thirteenth Edition), Related terms: Peptide; Gastrin; Synaptophysin; Phosphoprotein; Granin; Nested Gene; Secretion (Process).

Abstract Background:Chromogranin A (CgA) has been shown to be a useful marker in the diagnosis of neuroendocrine (NE) tumours. The clinical significance of CgA has been studied mostly in patients with known NE tumours. The diagnosis was evaluated in consecutive patients in whom CgA was measured in a given time by:   To the Editor, Human chromogranin A (CgA) is a secretory protein that is used as a tissue marker for neuroendocrine tumors (NETs) (1,2).

In patients with carcinoids and pheochromocytomas, CgA is a. The following is a collection of reference materials about Chromogranin A. The links in this document are to abstracts, unless noted.

Chromogranin A, Neuron Specific Enolase, CEA, and Hydroxyindole Acetic Acid Evaluation in Patients with Neuroendocrine Tumors. Bajetta E, et al.

Cancer Sep 1;86(5) “There appears to be a direct correlation between tumor burden. Chromogranin A is elevated to several times the upper limit of the reference range in 90% of patients with carcinoid syndrome.

Chromogranin A is particularly useful for diagnosing mid and hindgut carcinoid tumors, since they may not secrete serotonin and 5-HIAA. Chromogranin A may be used to detect residual or recurrent disease in treated patients.

Chromogranin A is a secretory protein. It is located in the large, dense-core vesicles of neuroendocrine cells. Chromogranin A-derived peptides are involved in a range of activities, like glucose metabolism, tumour angiogenesis, regulation of blood pressure and neuroprotection.

There are various causes of elevated chromogranin A (CgA) levels that are unrelated to neuroendocrine tumors. The most common causes of non-neuroendocrine tumors (false-positive result) encountered in the clinical practice is the use of proton pump inhibitors (PPIs), atrophic gastritis cases and impaired kidney g: book.

Chromogranin A - Chromogranin A (CgA) is used as an adjunct in the diagnosis of carcinoid tumors. Measurements of CgA are also used to assess disease progression, response to therapy, or recurrence after surgical g: book. Keywords:Prostate cancer, chromogranin A, PSA, bone scan, gleason score.

Abstract: Introduction: Neuroendocrine cells of the prostate are regulatory cells containing biogenic amines and certain neuropeptides such as chromogranin A (CgA). In the present study we evaluated the usefulness of serum CgA for monitoring prostate cancer progression.

Chromogranin A (CgA) is a tumor marker for such tumors; however, to the authors' knowledge, there is little information on whether serial assessments can assess changes in tumor burden. In this prospective study of patients with gastrinomas, serial changes in serum CgA levels were compared with changes in levels of the specific tumor marker.

Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as is a member of the granin family of proteins.

It can be used both for immunohistochemical stains and as a serum marker Immunohistochemistry. Chromogranin A is useful in identifying tissues of neuroendocrine origin, especially neuroendocrine tumors, as well as.

Chromogranin A (CgA) is a protein released from neuroendocrine cells. These are cells that release hormones in response to signals from the nervous system. They are found in organs throughout the body. This test measures the amount of chromogranin A in the g: book.

Chromogranins are a group of acidic, soluble secretory proteins. The most widely studied chromogranin is CgA, which was first isolated from chromaffin cells of the adrenal medulla. 3 CgA is a single polypeptide chain of amino acids and 10 dibasic cleavage g: book.

iii Preface Accretion “ the wisdom that accrues with age” It is a fi tting tribute that the 4th edition of the Neuroendocrine Tumors handbook falls on the 40th anniversary of Inter Science Institute (ISI).

The publication arising since the third edition is testimony to the progress of the science. Numerous studies have demonstrated that chromogranin A represents the single most specific marker of NE differentiation in general use.

Antibodies to chromogranin B and secretogranin II are available but are not in general use. Tissue-specific patterns and ratios of the chromogranin proteins are typically maintained in NE tumors. The Chromogranin A [CgA] blood test is ordered when there is a suspicion of a carcinoid syndrome present within a patient.

It may also be routinely ordered to monitor the treatment of such a syndrome. In its early stages, carcinoid syndrome can be very difficult to detect.

Many of the signs and symptoms of it Missing: book. Search the world's most comprehensive index of full-text books. My libraryMissing: chromogranin. About this study. The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II KRYPTOR Assay in patients with Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs).

Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed).Displays antibacterial activity against Gram-positive bacteria andand Gram-negative bacteria and nosa (PubMed and PubMed).Can induce mast cell migration, Missing: book.

One hundred and twenty‐seven patients entered the study. Multiple blood and 24‐hour urine specimens were assayed for biomarker quantitation.

RESULTS. The accuracy of each marker was assessed in patients with (n = ) and without (n = 21) disease. CgA proved to be the best marker (specificity of % and sensitivity of %).

Serum chromogranin A level. The measurement result of the serum CGA level in each group is shown in Table Table2. mean serum CGA level of patients with pNET was fold higher than in the controls and was significantly higher compared with the controls (P Missing: book.